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The effect of celiprolol on glomerular filtration rate and renal blood flow in patients with chronic renal impairment and healthy volunteers.
Author(s) -
Robson RA,
Bridgman PG,
Wells JE,
Bailey RR,
Lynn KL
Publication year - 1992
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1992.tb04068.x
Subject(s) - celiprolol , renal function , medicine , urology , renal blood flow , placebo , chronic renal insufficiency , endocrinology , heart rate , blood pressure , pathology , alternative medicine
A double‐blind, placebo controlled study investigated the effects of celiprolol, 200 mg daily for 7 days, on glomerular filtration rate (GFR) and estimated renal blood flow (ERBF) in eight healthy volunteers and eight patients with chronic renal insufficiency. In healthy volunteers the mean difference in GFR was 4.8 ml min‐1 (95% CI ‐8.2 to 17.7 ml min‐1) and the mean difference in ERBF was 49.8 ml min‐1 (95% CI ‐47.5 to 147 ml min‐1) after celiprolol. In patients with chronic renal insufficiency the mean difference in GFR was ‐2.1 ml min‐1 (95% CI ‐64.6 to 65.8 ml min‐1). The study had sufficient power to detect a 15% change in GFR for normals and 10% for patients, and for ERBF, changes of 14% and 23% were detectable. Celiprolol at a dose of 200 mg daily for 7 days can be used in patients with chronic renal insufficiency without adversely affecting GFR or ERBF.