Premium
Pharmacokinetics of dipipanone after a single oral dose.
Author(s) -
Paterson S
Publication year - 1992
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1992.tb04066.x
Subject(s) - pharmacokinetics , urine , half life , oral dose , chemistry , plasma concentration , oral administration , chromatography , pharmacology , medicine
A single oral dose of Diconal (dipipanone HCl 10 mg, cyclizine HCl 30 mg) was given to six volunteers. The mean peak plasma dipipanone concentration was 29 ng ml‐1, the time to peak plasma concentration was 1‐2 h, the mean elimination half‐life was 3.5 h and the mean AUC was 156 ng ml‐1 min. Less than 1% of the dose was excreted in urine unchanged over 24 h.