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Sumatriptan and cerebral perfusion in healthy volunteers.
Author(s) -
Scott AK,
Grimes S,
Ng K,
Critchley M,
Breckenridge AM,
Thomson C,
Pilgrim AJ
Publication year - 1992
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1992.tb04058.x
Subject(s) - sumatriptan , perfusion , medicine , cerebral perfusion pressure , anesthesia , cerebral blood flow , blood pressure , adverse effect , cerebrovascular circulation , migraine , pulse (music) , receptor , engineering , detector , electrical engineering , agonist
1. The effect of sumatriptan on regional cerebral perfusion was studied in healthy volunteers. 2. Intravenous sumatriptan (2 mg) had no detectable effect on regional cerebral perfusion as measured using a SPECT system with 99technetiumm labelled hexemethylpropyleneamineoxime. 3. Sumatriptan had no effect on pulse, blood pressure or ECG indices. 4. All six volunteers experienced minor adverse effects during the intravenous infusion.