Premium
The distribution of cis‐ and trans‐acitretin in human epidermis.
Author(s) -
Meyer E,
Lambert W,
Leenheer A,
Bersaques J,
Kint A
Publication year - 1992
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1992.tb04023.x
Subject(s) - acitretin , metabolite , dosing , active metabolite , pharmacokinetics , pharmacology , epidermis (zoology) , stratum corneum , chemistry , medicine , dermatology , psoriasis , pathology , anatomy
The concentrations of trans‐acitretin and its principal metabolite, cis‐ acitretin, were measured by h.p.l.c. after single and multiple dosing (50 mg orally for 13 days) in plasma, blister fluid and epidermal samples from four healthy male volunteers. Within‐day epidermal concentrations of trans‐acitretin exceeded those of the cis‐form which were at the limit of assay sensitivity. No accumulation of trans‐ acitretin was observed in plasma or blister fluid but AUC values for the drug in blister roof cells tended to be higher after multiple dosing.