Premium
A comparison of the effect of salmeterol and salbutamol in normal subjects.
Author(s) -
Spring J,
Clague J,
Ind PW
Publication year - 1992
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1992.tb04015.x
Subject(s) - salbutamol , salmeterol , bronchodilator , placebo , anesthesia , medicine , inhalation , asthma , alternative medicine , pathology
1. The effects of salmeterol hydroxynaphthoate (50 micrograms, 8.3 x 10(‐8) M) and salbutamol (200 micrograms, 3.5 x 10(‐7) M) on sGaw were compared in a double‐blind, placebo‐controlled, randomised study in 10 normal subjects. 2. SGaw increased by 29% (14‐43) (mean (CI)), 5 min after salmeterol and by 35% (19‐51) at 15 min compared with an increase of 32% (14‐51) and 37% (10‐63) after salbutamol and 4% (‐3‐11) and 8% (0‐16) after placebo. 3. The mean area under the sGaw‐time curve (AUC480) after salmeterol inhalation was 22,500 kPa‐1 (10,100‐39,500) compared with 14100 kPa‐1 (8020‐24,500) after salbutamol and 5300 kPa‐1 (1500‐10,400) after placebo. 4. Salmeterol produced a significantly prolonged bronchodilator effect compared with salbutamol in normals.