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Lack of effect of flosequinan on the pharmacokinetics of theophylline.
Author(s) -
Kamali F.,
Edwards C.,
Rawlins MD
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05624.x
Subject(s) - theophylline , pharmacokinetics , cmax , oral administration , bronchodilator , medicine , pharmacology , crossover study , drug interaction , urine , asthma , placebo , alternative medicine , pathology
The pharmacokinetics of theophylline (240 mg) p.o. were studied before and after the administration of oral flosequinan for 14 days in 21 healthy volunteers using a randomised cross‐over design. Comparisons of Cmax, tmax, AUC, CL of theophylline and urinary recovery of the parent drug and metabolites showed that flosequinan had no significant effect on the disposition of theophylline.