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No effect of probenecid on the renal and biliary clearances of digoxin in man.
Author(s) -
Hedman A.,
Angelin B.,
Arvidsson A.,
Dahlqvist R.
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05614.x
Subject(s) - probenecid , digoxin , volume of distribution , pharmacokinetics , renal function , medicine , endocrinology , pharmacology , cardiac glycoside , chemistry , heart failure , ouabain , organic chemistry , sodium
1. The cardiac glycoside digoxin is subject to a number of pharmacokinetic interactions. This study concerns the influence of the anionic transport inhibitor probenecid on the steady‐state kinetics of digoxin. 2. Six healthy young men were enrolled in the study. After an administration period of 6 days with digoxin only (0.5 to 1 mg p.o. day‐ 1) or digoxin in combination with probenecid (2 g p.o. day‐1; 8 days), digoxin was administered intravenously (0.7 oral dose) on day 7. Plasma and urine samples were taken over 48 h. The biliary clearance of digoxin was measured during day 8 by a duodenal perfusion technique. 3. Probenecid did not affect the plasma clearance (mean +/‐ s.d.: 255 +/‐ 80 vs 266 +/‐ 40 ml min‐1), renal clearance (166 +/‐ 17 vs 155 +/‐ 10 ml min‐1), biliary clearance (106 +/‐ 40 vs 111 +/‐ 50 ml min‐1), elimination half‐life (34.4 vs 35.2 h) or volume of distribution (538 +/‐ 241 vs 566 +/‐ 60 l) of digoxin. 4. Our results suggest that different systems exist in man for the renal and biliary secretion of probenecid and digoxin.