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Transdermal nitrate therapy: bioavailability during exercise increases transiently after the daily change of patch.
Author(s) -
Gjesdal K.,
Klemsdal TO,
Rykke EO,
Bredesen JE
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05582.x
Subject(s) - transdermal , bioavailability , plasma concentration , transdermal patch , nitrate , pharmacology , pharmacokinetics , medicine , chemistry , anesthesia , organic chemistry
Ten volunteers carried a 10 mg 24 h −1 transdermal glyceryl trinitrate (GTN) patch for 24 h before moderate exercise. Plasma GTN‐concentration increased significantly (P less than 0.05) by 19% to peak value at 15 min. Two hours after patch renewal repeat exercise increased GTN concentration by 56% (P less than 0.001). The two nitrate‐concentration curves differed significantly (P less than 0.0001). Thus, change of patch augmented nitrate availability during exercise.