Premium
A comparison of serum and saliva paracetamol concentrations.
Author(s) -
Smith M.,
Whitehead E.,
O'Sullivan G.,
Reynolds F.
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05580.x
Subject(s) - saliva , pharmacology , medicine , chemistry
The relationship between serum and saliva paracetamol concentrations was investigated in twenty healthy volunteers. The plasma and saliva drug concentrations showed a significant correlation (r = 0.67). However the agreement between the two methods of measurement was poor with limits of agreement of −15.3 mg l‐1 to +15.9 mg l‐1 with mean sample values of 19.2 and 19.5 mg l‐1 for plasma and saliva, respectively.