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A comparison of drug protein binding and alpha 1‐acid glycoprotein concentration in Chinese and Caucasians.
Author(s) -
Feely J.,
Grimm T.
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05579.x
Subject(s) - orosomucoid , plasma protein binding , medicine , warfarin , alpha (finance) , pharmacology , binding site , endocrinology , glycoprotein , chemistry , biochemistry , surgery , construct validity , patient satisfaction , atrial fibrillation
alpha 1‐acid glycoprotein (AAG) concentration and the binding of both lignocaine and warfarin were compared in 15 healthy Chinese and age and sex matched Irish (Caucasian) subjects. Both the extent of lignocaine binding and AAG concentrations were significantly (P less than 0.05) lower in Chinese subjects. No difference was shown in warfarin binding. These results suggest that the binding of basic drugs may be significantly less in Chinese than Caucasians, and lower concentrations of the binding protein AAG are a major determinant of this difference.