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Effect of zinc supplementation on oxidative drug metabolism in patients with hepatic cirrhosis.
Author(s) -
Barry MG,
Macmathuna P.,
Younger K.,
Keeling PW,
Feely J.
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05568.x
Subject(s) - zinc , cirrhosis , volume of distribution , medicine , pharmacokinetics , drug metabolism , metabolism , endocrinology , drug , chemistry , oxidative phosphorylation , zinc deficiency (plant disorder) , pharmacology , biochemistry , organic chemistry
The pharmacokinetics of antipyrine were studied in seven zinc deficient patients with hepatic cirrhosis, before and after zinc supplementation. Each patient received zinc sulphate 660 mg daily for 30 days, restoring zinc status to normal as assessed by leucocyte zinc concentration. Antipyrine clearance was significantly reduced (P less than 0.05) and antipyrine elimination half‐life increased (P less than 0.05) following administration of zinc sulphate without significant alteration in the apparent volume of distribution. It is concluded that supplementation of the zinc deficiency associated with hepatic cirrhosis impaired the hepatic oxidative metabolism of antipyrine.