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A comparison of the hypoalgesic effect of paracetamol in slow‐release and plain tablets on laser‐induced pain.
Author(s) -
Nielsen JC,
Bjerring P.,
ArendtNielsen L.
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05528.x
Subject(s) - hypoalgesia , placebo , analgesic , anesthesia , medicine , acetaminophen , double blind , pain relief , nociception , hyperalgesia , receptor , alternative medicine , pathology
1. In a double‐blind, three way, cross‐over study 15 volunteers received plain paracetamol tablets 1000 mg every 6th hour, paracetamol slow‐release tablets 2000 mg every 12th hour, and placebo. Steady state conditions were established over a 5 day period preceding each test session. 2. Plain paracetamol was given twice in the 12h test session, initially and after 6 h, and the slow‐release formulation was given once at the start of the session. 3. Hypoalgesia, measured by experimentally laser‐induced pain (pain threshold), and plasma concentrations of paracetamol were measured hourly for 12 h. 4. Both formulations of paracetamol were significantly superior (P = 0.0003) to placebo, but not difference in analgesic efficacy was found between the two regimens.