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Influence of menstrual cycle phase on serum concentrations of alpha 1‐ acid glycoprotein.
Author(s) -
Parish RC,
Spivey C.
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05515.x
Subject(s) - menstrual cycle , orosomucoid , endocrinology , serum concentration , alpha (finance) , medicine , chemistry , glycoprotein , pharmacology , hormone , biochemistry , surgery , construct validity , patient satisfaction
Serum concentrations of alpha 1‐acid glycoprotein (AAG) were studied in nine healthy women at four times in their menstrual cycles. AAG concentrations were significantly higher on day 4 than on days 12, 20, and 28 (with the first day of menstrual flow considered to be day 1). The mean AAG concentration (mg dl‐1) on day 4 was 78.55 +/‐ 5.03 (mean +/‐ s.e. mean), 70.19 +/‐ 4.80 on day 12, 70.63 +/‐ 6.67 on day 20, and 70.40 +/‐ 5.97 on day 28. Although these results should be considered preliminary because of the small sample size, we conclude that physiologic changes over the course of the menstrual cycle may affect serum AAG concentrations. Since AAG is a major binding protein for several important drugs, the potential exists for altered drug binding and drug effects, and further study of individual drugs is justified.