Premium
A dose‐response study examining the effects of ritanserin on human slow wave sleep.
Author(s) -
Idzikowski C.,
Mills FJ,
James RJ
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05514.x
Subject(s) - ritanserin , placebo , diazepam , sleep (system call) , crossover study , medicine , slow wave sleep , anesthesia , randomized controlled trial , dose–response relationship , electroencephalography , serotonin , psychiatry , 5 ht receptor , receptor , alternative medicine , pathology , computer science , operating system
This study investigated the effects of placebo, 1 mg, 3 mg, 10 mg and 30 mg ritanserin and 10 mg diazepam on human sleep. Twelve normal volunteers participated in this randomized, double‐blind, placebo‐ controlled cross‐over sleep study. A clear dose‐response relationship was found for ritanserin with higher doses evoking increased duration of slow wave sleep.