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The pharmacokinetics of postoperative intravenous ketorolac tromethamine in children.
Author(s) -
Olkkola KT,
Maunuksela EL
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05510.x
Subject(s) - ketorolac tromethamine , pharmacokinetics , volume of distribution , anesthesia , medicine , plasma clearance , ketorolac , half life , plasma volume , plasma concentration , pharmacology , analgesic
Ketorolac tromethamine (0.5 mg kg‐1) was given intravenously to 10 children (age 4‐8 years) after minor surgery. Values of steady‐state volume of distribution and plasma clearance were approximately two times higher than those in adults but values of elimination half‐life were similar.