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Lack of pharmacokinetic interaction between nifedipine, sparteine and phenytoin in man.
Author(s) -
Schellens JH,
Soons PA,
Wart JH,
Hoevers JW,
Breimer DD
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05508.x
Subject(s) - sparteine , nifedipine , phenytoin , pharmacology , pharmacokinetics , drug interaction , urine , chemistry , drug , oral administration , cyp2d6 , cytochrome p450 , metabolism , medicine , biochemistry , calcium , stereochemistry , epilepsy , organic chemistry , psychiatry
Nifedipine, sparteine and phenytoin were administered orally to eight healthy subjects separately and as a 'cocktail' on four different occasions to investigate any kinetic interactions. All subjects were extensive metabolizers of sparteine. After drug intake plasma and urine samples were collected up to 32 h and the concentrations of parent drugs and main metabolites were measured. Clearances and formation clearances were not significantly different after single substrate and 'cocktail' administration. Low or non significant correlation coefficients were found between the oxidation of the individual substrates or formation of their metabolites. With this strategy of simultaneous administration of substrates ('cocktail') it appears possible to characterize (and correlate) activities of different cytochrome P‐450 isoenzymes, without the disturbing influence of intraindividual variation of drug oxidation with time.