Premium
A comparison of the pharmacokinetic properties of streptokinase and anistreplase in acute myocardial infarction.
Author(s) -
Gemmill JD,
Hogg KJ,
Burns JM,
Rae AP,
Dunn FG,
Fears R.,
Ferres H.,
Standring R.,
Greenwood H.,
Pierce D.
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb05502.x
Subject(s) - streptokinase , pharmacokinetics , myocardial infarction , clearance , medicine , half life , pharmacology , distribution (mathematics) , anesthesia , urology , mathematical analysis , mathematics
1. The pharmacokinetics of streptokinase (SK) and anistreplase in conventional dosage regimens of 1.5 x 10(6) i.u. of SK infused over 60 min and 30 units of anistreplase over 5 min were studied in 24 consecutive patients presenting with acute myocardial infarction, using a functional bioassay to assess concentrations. 2. The two agents were found to have similar volumes of distribution (5.68 and 5.90 l), but SK was cleared significantly more rapidly than anistreplase, resulting in a shorter terminal phase half‐life (0.61 vs 1.16 h) and a shorter mean residence time (0.76 vs 1.55 h).