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Oral amino acids and gastric emptying: an investigation of the mechanism of levodopa‐induced gastric stasis.
Author(s) -
Waller DG,
Usman F,
Renwick AG,
Macklin B,
George CF
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03990.x
Subject(s) - gastric emptying , mechanism (biology) , gastroenterology , levodopa , medicine , pharmacology , chemistry , stomach , disease , parkinson's disease , philosophy , epistemology
To investigate possible mechanisms of levodopa‐induced gastric stasis, we have studied the effect of other amino acids on gastric emptying. The large neutral amino acid tryptophan delays gastric emptying in the dog at molar concentrations below those required to stimulate duodenal osmoreceptors. In healthy volunteers, we have shown that neither tryptophan nor the small neutral amino acid glycine delayed gastric emptying when given in concentrations similar to those of levodopa which produce gastric stasis. The study suggests that levodopa does not inhibit gastric emptying by an effect on duodenal amino acid receptors or via osmoreceptors.