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The effect of age on glucuronidation and sulphation of paracetamol by human liver fractions.
Author(s) -
Herd B,
Wynne H,
Wright P,
James O,
Woodhouse K
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03989.x
Subject(s) - glucuronidation , sulfation , enzyme , liver enzyme , pharmacology , chemistry , acetaminophen , sulfotransferase , in vitro , enzyme assay , endocrinology , medicine , biochemistry , microsome
Glucuronidation and sulphation were studied in vitro in human liver samples from 22 subjects aged 40‐89 years using paracetamol as substrate. There was no significant correlation with age for the activity of either enzyme pathway. These results provide further evidence that age per se does not have a major effect on the activities of hepatic metabolising enzymes.