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Interethnic differences in drug glucuronidation: a comparison of paracetamol metabolism in Caucasians and Chinese.
Author(s) -
Osborne NJ,
Tonkin AL,
Miners JO
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03988.x
Subject(s) - glucuronidation , drug metabolism , pharmacology , drug , medicine , pharmacokinetics , acetaminophen , oral administration , sulfation , metabolism , chemistry , biochemistry , microsome , enzyme
Paracetamol disposition following a single oral 1 g dose of the drug was compared in groups (n = 12) of healthy young adult male Caucasians and Chinese. There was no difference between the groups in terms of paracetamol oral clearance, elimination half‐life, or partial metabolic (glucuronidation, sulphation, oxidation) and renal clearances. The results demonstrate that drug glucuronidation is not universally impaired in Chinese and, together with previously published data, that paracetamol glucuronidation is minimally affected by race.