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Ouabain and responses to endothelium‐dependent vasodilators in the human forearm.
Author(s) -
Woolfson RG,
Benjamin N,
Todd SD,
Poston L,
Ritter JM
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03986.x
Subject(s) - bradykinin , ouabain , vasodilation , sodium nitroprusside , endothelium , brachial artery , endocrinology , medicine , forearm , chemistry , pharmacology , sodium , nitric oxide , blood pressure , surgery , receptor , organic chemistry
Ouabain inhibits endothelium‐dependent vascular relaxation in vitro, but has not been studied in this regard in vivo. We have therefore measured blood flow responses to carbachol, bradykinin and sodium nitroprusside (endothelium‐dependent and endothelium‐independent vasodilators) infused into the brachial artery with and without co‐ infusion of ouabain (2 micrograms min‐1). Six healthy male volunteers were each studied on two occasions. Ouabain reduced basal forearm blood flow, by 18.0 +/‐ 4.1% (mean +/‐ s.e. mean, 2P less than 0.05), but had no significant effect on responses to any of the three vasodilators. These results indicate that effects of ouabain on endothelium‐dependent relaxation in vitro must be interpreted with caution.