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Lack of systematic effects of the 5‐hydroxytryptamine 3 receptor antagonist ICS 205‐930 on gastric emptying and antral motor activity in patients with primary anorexia nervosa.
Author(s) -
Stacher G,
Bergmann H,
GranserVacariu GV,
Wiesnagrotzki S,
Wenzelabatzi TA,
Gaupmann G,
Kugi A,
Steinringer H,
Schneider C,
Hobart J
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03974.x
Subject(s) - gastric emptying , antrum , medicine , placebo , stomach , prokinetic agent , gastroenterology , contractility , antagonist , crossover study , endocrinology , anorexia nervosa , anorexia , receptor , pathology , eating disorders , alternative medicine , psychiatry
1. The 5‐hydroxytryptamine 3 receptor antagonist, ICS 205‐930, has been reported to have potent effects on gastric smooth muscle and to enhance gastric emptying in animals, but findings in man have been inconsistent. 2. This study investigated the effects of ICS 205‐930 on gastric emptying of an isotopically labelled semisolid 1168 kJ meal and on antral contractility in patients with primary anorexia nervosa, a condition frequently associated with impaired gastric motor function. 3. Thirteen female patients (age 18‐39 years, median 22 years; percentage of ideal body weight 52‐90%, median 66%) participated each in two studies, in which 0.15‐0.18 mg kg‐1 ICS 205‐930 or placebo were infused i.v. in crossover, double‐blind fashion. Gastric emptying and antral contractility were recorded scintigraphically for 50 min. 4. ICS 205‐930 did not affect gastric emptying: the mean percentage of meal remaining in the stomach after 50 min (69.6% +/‐ 3.2 s.e. mean) was nearly identical to that after placebo (70.7 +/‐ 3.3%). 5. Amplitude, frequency and propagation velocity of antral contractions differed only little after ICS 205‐930 and placebo, respectively. 6. The results show that ICS 205‐930 has no effect on the impaired gastric motor activity in primary anorexia nervosa and thus provide further evidence that the compound does not have prominent prokinetic effects in man.