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Circadian changes in estimated hepatic blood flow in healthy subjects.
Author(s) -
Lemmer B,
Nold G
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03964.x
Subject(s) - circadian rhythm , indocyanine green , supine position , blood flow , medicine , endocrinology , volume of distribution , plasma clearance , pharmacokinetics , surgery
Intravenous injections of indocyanine green (ICG) were given to 10 healthy supine subjects at 02.00, 08.00, 14.00 and 20.00 h. ICG plasma half‐life, plasma clearance and estimated hepatic blood flow (EHBF), but not volume of distribution, varied significantly with time of day with EHBF being greatest at 08.00 h. This circadian rhythm in EHBF should be considered when evaluating the kinetics of high‐clearance drugs at different times of day.