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Plasma metronidazole concentrations after single and repeated vaginal pessary administration.
Author(s) -
SalasHerrera IG,
Lawson M,
Johnston A,
Turner P,
Gott DM,
Dennis MJ
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03962.x
Subject(s) - metronidazole , anaerobic exercise , minimum inhibitory concentration , pharmacokinetics , area under the curve , oral administration , chemistry , pharmacology , medicine , antibiotics , physiology , biochemistry
Metronidazole concentrations in plasma were measured by h.p.l.c. in 12 healthy female volunteers after single and repeated vaginal administration of 500 mg metronidazole pessaries. The area under the plasma concentration‐time curve (AUC(0,12 h) was 8.4 +/‐ 3.9 micrograms ml‐1 h (mean +/‐ s.d.) on day 1 and 20.6 +/‐ 7.1 micrograms ml‐1 h (mean +/‐ s.d.) on day 5. The peak plasma drug concentration on day 1 was 1.2 +/‐ 0.6 micrograms ml‐1 (mean +/‐ s.d.) and on day 5 it was 2.0 +/‐ 0.7 micrograms ml‐1 (mean +/‐ s.d.). The plasma concentration of metronidazole at steady state was above the minimum inhibitory concentration (MIC) for anaerobic Streptococci and Clostridium tetani. These results demonstrate much lower systemic exposure than after oral administration.