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Further insight into the stereoselective interaction between warfarin and cimetidine in man.
Author(s) -
Niopas I,
Toon S,
Rowland M
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03940.x
Subject(s) - cimetidine , warfarin , pharmacology , medicine , drug interaction , oral administration , pharmacokinetics , atrial fibrillation
The urinary profile of R‐ and S‐warfarin, following administration of a single (25 mg) oral dose of racemic warfarin, alone or on day 4 of a 9‐ day chronic administration of cimetidine (800 mg once daily), was investigated in eight healthy male volunteers. Based on estimated apparent formation clearance values, cimetidine inhibited significantly only the formation of R‐6‐hydroxywarfarin and R‐7‐hydroxywarfarin.