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Polymorphisms in oxidative drug metabolism: relationship to food preference.
Author(s) -
Britto MR,
McKean HE,
Bruckner GG,
Wedlund PJ
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03887.x
Subject(s) - mephenytoin , dextromethorphan , food preference , pharmacogenetics , drug metabolism , biology , drug , pharmacology , biochemistry , food science , genotype , gene
To determine whether a correlation exists between polymorphisms of oxidative drug metabolism and dietary preference, 29 poor metabolizers of dextromethorphan, 18 poor metabolizers of mephenytoin and 134 extensive metabolizers of both drugs were screened for their preferences for various food items. Poor metabolizers of dextromethorphan showed a diminished stated preference for cauliflower and coconut, and poor metabolizers of mephenytoin showed a diminished stated preference for spinach and cabbage.