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Effects of clonidine and yohimbine on the pupillary light reflex and carbachol‐evoked sweating in healthy volunteers.
Author(s) -
Morley MJ,
Bradshaw CM,
Szabadi E
Publication year - 1991
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1991.tb03864.x
Subject(s) - clonidine , yohimbine , carbachol , reflex , crossover study , medicine , placebo , anesthesia , hyperventilation , endocrinology , antagonist , stimulation , receptor , alternative medicine , pathology
The effects of single doses of clonidine hydrochloride (200 micrograms), yohimbine hydrochloride (22 mg), a combination of the two treatments, and placebo, on some autonomic functions were studied in healthy volunteers using a double‐blind crossover design. Clonidine prolonged the recovery time of the light reflex, lowered systolic blood pressure and reduced subjectively rated alertness; these effects were reversed by yohimbine. Responsiveness of sweat glands to carbachol was not affected by the treatments.