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Receptor modification in the brains of spontaneously hypertensive and Wistar‐Kyoto rats: regionally specific and selective increase in cerebellar beta 2‐adrenoceptors.
Author(s) -
Jones CR,
Palacios JM,
Hoyer D.,
Buhler FR
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb05498.x
Subject(s) - beta (programming language) , adrenergic receptor , beta adrenoceptor , cerebellum , medicine , receptor , endocrinology , pharmacology , chemistry , computer science , programming language
Quantitative in vitro autoradiography was used to study beta‐adrenergic and benzodiazepine receptor density in discrete regions from sagittal brain sections of 20 week old hypertensive (SHR) and normotensive (WKY) rats. The density of beta‐adrenoceptors was increased by 68% in the granule cell layer of the cerebellum of the SHR without a change in receptor affinity; this increase was specific for receptors of the beta 2‐subtype. On the other hand, benzodiazepine receptor density was unchanged in the cerebella of SHR. These results indicate that brain beta‐adrenoceptors are differentially modulated by the hypertensive state which may be either a cause or a consequence of alterations in adrenergic nervous system activity found in the SHR.