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Effect of calcium and beta‐adrenoceptor antagonists on beta‐ adrenoceptor density and Gs alpha expression in human atria.
Author(s) -
Jones CR,
Fandeleur P.,
Harris B.,
Buhler FR
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb05497.x
Subject(s) - beta (programming language) , nifedipine , propranolol , sotalol , beta 1 adrenergic receptor , endocrinology , alpha (finance) , medicine , antagonist , adrenergic receptor , receptor , beta 3 adrenergic receptor , calcium , pharmacology , chemistry , construct validity , nursing , computer science , programming language , patient satisfaction , atrial fibrillation
In 21 patients undergoing open heart surgery the effects of the beta‐ adrenoceptor antagonists propranolol and sotalol and the calcium antagonist nifedipine (alone or in combination) on right atrial beta‐ adrenoceptor density and G protein expression were studied. The non‐ selective beta‐adrenoceptor antagonists increased both right atrial beta 1‐ and beta 2‐adrenoceptor density; this increase was not affected by nifedipine. There was no correlation between beta‐adrenoceptor density and expression of the G protein subunit Gs alpha suggesting independent regulation of the gene expression for G proteins and their coupled receptors.