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Parainfluenza‐3 induced hyperreactivity of the guinea pig trachea coincides with an increased number of bronchoalveolar cells.
Author(s) -
Folkerts G.,
Janssen M.,
Nijkamp FP
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb05493.x
Subject(s) - histamine , guinea pig , respiratory system , immunology , saline , medicine , contraction (grammar) , pi , biology , biochemistry
Guinea pigs were inoculated intra‐tracheally with bovine parainfluenza type 3 virus (PI‐3) to investigate whether airway hyperreactivity was associated with an increase in the number of broncho‐alveolar cells. Two days after saline or PI‐3 inoculation no difference in histamine reactivity of the isolated tracheal spirals was observed. The number of broncho‐alveolar cells was also not changed. However, 4 days after PI‐3 inoculation the histamine‐induced contraction of the tracheal spirals was increased by 45% and the number of inflammatory cells in the airways by 150% as compared with the control group. In conclusion, PI‐3 infection of the guinea pig respiratory airways induces tracheal hyperreactivity which is associated with an increase in broncho‐ alveolar cells.