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Neutrophils increase histamine contractions in pig coronary artery: a role for lipoxygenase products.
Author(s) -
HeuvenNolsen D.,
Have GA,
Nijkamp FP
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb05492.x
Subject(s) - histamine , lipoxygenase , medicine , pharmacology , cardiology , anesthesia , chemistry , biochemistry , enzyme
The possible role of neutrophils and the endothelium in the induction of hyperreactivity of the pig coronary artery to histamine was studied. In pig isolated coronary arteries histamine caused a concentration‐ dependent contraction; maximal contraction to histamine, however, was reduced in endothelium‐denuded arteries. Pre‐incubation of intact coronary arteries with isolated neutrophils did not affect the contractile response to histamine, while pre‐incubation of endothelium‐ denuded arteries induced a hyperreactivity to histamine. This induction of hyperreactivity to histamine by neutrophils in pig coronary arteries seems to be mediated by lipoxygenase products, since it could be prevented by pre‐incubation of the preparations with lipoxygenase inhibitors, but not with inhibitors of cyclo‐oxygenase or with scavengers.