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The relationship between adrenaline and beta 2‐adrenoceptors on human lymphocytes.
Author(s) -
Graafsma SJ,
Hectors MP,
Tits LJ,
Rodrigues de Miranda JF,
Thien T.
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb05488.x
Subject(s) - endocrinology , medicine , adrenalectomy , beta (programming language) , mental arithmetic , epinephrine , adrenergic receptor , alpha (finance) , receptor , blood pressure , heart rate , construct validity , nursing , computer science , patient satisfaction , programming language
To study the relation between plasma adrenaline (AD) and noradrenaline (NA) and the beta 2‐adrenoceptor number (Bmax) on lymphocytes these variables were measured in the following three groups: a) In 67 normotensive volunteers after a rest period of at least 15 min. b) In 10 essential hypertensive (HT) and 10 age and sex matched normotensive (NT) subjects before and after a standardized bicycle exercise test (BE). c) In 10 bilaterally adrenalectomized females (AF) and 10 healthy age matched females (NF) before and after a mental arithmetic test (MA). Significant correlations were found between AD and Bmax in NT (r = 0.30, P = 0.015) and between the proportional increase in AD and the proportional increase in Bmax after BE (r = 0.60, P less than 0.005). The MA induced elevation of Bmax was blunted after adrenalectomy. All these findings point to a relation between AD and beta 2‐adrenoceptor regulation.