The relationship between adrenaline and beta 2‐adrenoceptors on human lymphocytes. | Zendy

Graafsma SJ | Zendy; Hectors MP | Zendy; Tits LJ | Zendy; Rodrigues de Miranda JF | Zendy; Thien T. | Zendy

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The relationship between adrenaline and beta 2‐adrenoceptors on human lymphocytes.

Author(s) -

Graafsma SJ,

Hectors MP,

Tits LJ,

Rodrigues de Miranda JF,

Thien T.

Publication year - 1990

Publication title -

british journal of clinical pharmacology

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.216

H-Index - 146

eISSN - 1365-2125

pISSN - 0306-5251

DOI - 10.1111/j.1365-2125.1990.tb05488.x

Subject(s) - endocrinology , medicine , adrenalectomy , beta (programming language) , mental arithmetic , epinephrine , adrenergic receptor , alpha (finance) , receptor , blood pressure , heart rate , construct validity , nursing , computer science , patient satisfaction , programming language

To study the relation between plasma adrenaline (AD) and noradrenaline (NA) and the beta 2‐adrenoceptor number (Bmax) on lymphocytes these variables were measured in the following three groups: a) In 67 normotensive volunteers after a rest period of at least 15 min. b) In 10 essential hypertensive (HT) and 10 age and sex matched normotensive (NT) subjects before and after a standardized bicycle exercise test (BE). c) In 10 bilaterally adrenalectomized females (AF) and 10 healthy age matched females (NF) before and after a mental arithmetic test (MA). Significant correlations were found between AD and Bmax in NT (r = 0.30, P = 0.015) and between the proportional increase in AD and the proportional increase in Bmax after BE (r = 0.60, P less than 0.005). The MA induced elevation of Bmax was blunted after adrenalectomy. All these findings point to a relation between AD and beta 2‐adrenoceptor regulation.

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