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Effects of insulin on human beta‐adrenoceptors.
Author(s) -
Sager G.
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb05486.x
Subject(s) - isoprenaline , medicine , insulin , endocrinology , beta (programming language) , stimulation , insulin sensitivity , beta adrenoceptor , chemistry , adrenergic receptor , insulin resistance , receptor , computer science , programming language
The effect of insulin on beta‐adrenoceptor stimulation and binding in mononuclear leucocytes from healthy subjects was studied. After 1 min exposure to insulin, the sensitivity and maximum response to (−)− isoprenaline and the number of beta‐adrenoceptors increased. After 35 min exposure to insulin, the sensitivity and maximal response to (−)− isoprenaline stimulation were lower than the pretreatment values. The beta‐adrenoceptor density was similar to the control value after 35 min exposure to insulin. The present observations may account for some of the cardiovascular effects of insulin.