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Contractions to 5‐hydroxytryptamine in human coronary artery and human saphenous vein.
Author(s) -
Borton M.,
Neligan M.,
Wood F.,
Dervan P.,
Goggins K.,
Docherty J.R.
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb05476.x
Subject(s) - ketanserin , vein , medicine , artery , cardiology , isometric exercise , receptor , receptor antagonist , antagonist , 5 ht2 receptor , human ear , 5 ht receptor , serotonin , physics , acoustics
Isometric contractions were obtained to 5‐hydroxytryptamine receptor agonists in human saphenous vein and human coronary artery. Based on the interaction with the 5‐HT2 receptor antagonist ketanserin, both 5‐ HT1 and 5‐HT2 receptors are involved in contractions of human saphenous vein, but the predominant subtype involved in contractions of human coronary artery is the 5‐HT1 receptor.