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Lack of effect of co‐trimoxazole on the pharmacokinetics and pharmacodynamics of nifedipine.
Author(s) -
Edwards C.,
Monkman S.,
Cholerton S.,
Rawlins MD,
Idle J.R.,
Ferner RE
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb05456.x
Subject(s) - nifedipine , pharmacokinetics , pharmacology , active metabolite , metabolite , pharmacodynamics , plasma concentration , medicine , oral administration , chemistry , calcium
The pharmacokinetics of nifedipine and its primary oxidised metabolite, M‐I were studied in nine healthy volunteers following a single oral dose of 20 mg nifedipine alone or after pretreatment with oral co‐ trimoxazole. Following pretreatment with co‐trimoxazole, no significant effect was detected on maximum plasma concentration, elimination half‐ life, or area under the plasma concentration‐time curve of either nifedipine or M‐I, nor on the blood pressure response to nifedipine.