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D‐penicillamine does not increase urinary bismuth excretion in patients treated with tripotassium dicitrato bismuthate.
Author(s) -
Nwokolo CU,
Pounder RE
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03829.x
Subject(s) - penicillamine , bismuth , urinary system , dosing , excretion , medicine , urine , oral administration , chemistry , urology , gastroenterology , organic chemistry
Twenty‐four urinary bismuth excretion was measured in five patients who had been treated with tripotassium dicitrato bismuthate, before and after single 1 g oral dose of D‐penicillamine. Before dosing with D‐ penicillamine, the median 24 h urinary bismuth output was 55 micrograms 24 h‐1 (range 17‐156 micrograms 24 h‐1) and following dosing with D‐ penicillamine the median 24 h urinary bismuth output was 53 micrograms 24 h‐1 (range 12‐156 micrograms 24 h‐1). D‐penicillamine does not facilitate the urinary excretion of bismuth, hence it is unsuitable for use as an oral chelator in patients with bismuth intoxication.