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Effect of UK‐52,046, an alpha 1‐adrenoceptor antagonist, on baroreflex function in man.
Author(s) -
McKaigue JP,
Harron DW
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03816.x
Subject(s) - antagonist , alpha (finance) , baroreflex , adrenergic receptor , medicine , pharmacology , adrenergic beta antagonists , endocrinology , receptor , heart rate , blood pressure , propranolol , surgery , construct validity , patient satisfaction
1. In a placebo controlled study (six healthy male subjects), the effects of UK‐52,046 (0.4 microgram kg‐1 i.v.) and prazosin (0.25 mg i.v.) on baroreflex function were compared, at doses which produced antagonism to phenylephrine, but which had no effect on supine blood pressure. 2. Baroreflex function [delta R‐R interval ms mm Hg‐1 change in SBP] was assessed following increases in systolic blood pressure (SBP) with phenylephrine and during the Valsalva manoeuvre. 3. At these doses neither UK‐52,046 nor prazosin had an effect on supine SBP or heart rate; however following prazosin, standing SBPs at 5 s (69.7 +/− 7.6 mm Hg) and at 3 min (65.5 +/− 11.7 mm Hg) were less than the respective pre‐treatment (P less than 0.05) values (96.0 +/− 2.9, 110.3 +/− 6.2 mm Hg) and placebo (82.7 +/− 5.6, 98.7 +/− 11.1 mm Hg). UK‐ 52,046 had no significant effects on standing SBP at 5 s or 3 min. At 5 s, pre‐ and post‐treatment R‐R intervals (584 +/− 26, 541 +/− 27 ms respectively) were not significantly different with prazosin, but at 3 min the post‐treatment R‐R interval following prazosin (519 +/− 17 ms) was less (P less than 0.05) than the pre‐treatment value (658 +/− 36 ms). 4. UK‐52,046 had no effect on baroreflex sensitivity (12.7 +/− 1.3 ms mm Hg‐1) compared with placebo (17.9 +/− 2.7 ms mm Hg‐1).(ABSTRACT TRUNCATED AT 250 WORDS)