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Changes in indocyanine green kinetics after the administration of enalapril to healthy subjects.
Author(s) -
Geneve J,
Dinh T,
Brouard A,
Bails M,
Segrestaa JM,
Caulin C
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03779.x
Subject(s) - indocyanine green , enalapril , kinetics , medicine , chemistry , pharmacology , endocrinology , surgery , blood pressure , angiotensin converting enzyme , physics , quantum mechanics
Enalapril maleate, an angiotensin converting enzyme inhibitor, is a vasodilator liable to modify regional blood flow. The effects of an oral dose of 40 mg enalapril maleate on indocyanine green (ICG) kinetics were assessed in nine healthy subjects. At 4 h after the administration of the drug, a 35% decrease in ICG clearance was observed (P less than 0.01) associated with a 23% decrease in its volume of distribution (P less than 0.02). The half‐life of ICG was not altered significantly by enalapril. These results suggest that the administration of enalapril maleate to healthy subjects may reduce apparent liver plasma flow and plasma volume, as a consequence of the pooling of blood in the hepatosplanchnic area.