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The excretion of zopiclone into breast milk.
Author(s) -
Matheson I,
Sande HA,
Gaillot J
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03774.x
Subject(s) - zopiclone , excretion , breast milk , medicine , urine , pharmacology , physiology , chemistry , hypnotic , biochemistry
1. The excretion of zopiclone into breast milk was studied in 12 lactating women in the early postpartum period following the oral administration of a single zopiclone tablet (7.5 mg). 2. The milk/plasma AUC ratio of zopiclone was 0.51 +/− 0.09 (mean +/− s.d.). Individual mean milk/plasma concentration ratios of zopiclone showed significant interindividual variation (range 0.41‐0.70). 3. A comparison of pharmacokinetic parameters in the postpartum women with those reported previously in non‐pregnant women, showed significantly higher Cmax values in the lactating mothers; tmax occurred later in milk than in maternal plasma. 4. Assuming a daily milk intake of 0.15 l kg‐1 and 100% absorption the average infant dose of zopiclone in milk would be 1.4% of the weight adjusted dose ingested by the mother.