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High dose eicosapentaenoic acid ethyl ester: effects on lipids and neutrophil leukotriene production in normal volunteers.
Author(s) -
Hawthorne AB,
Filipowicz BL,
Edwards TJ,
Hawkey CJ
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03764.x
Subject(s) - eicosapentaenoic acid , leukotriene , pharmacology , leukotriene c4 , medicine , leukotriene b4 , ethyl ester , neutrophile , inflammation , chemistry , immunology , biochemistry , polyunsaturated fatty acid , fatty acid , organic chemistry , asthma
1. A 93% pure ethyl ester of eicosapentaenoic acid was investigated for tolerability and biochemical effects on neutrophil leukotriene synthesis and plasma lipoproteins when given in high dose. Six healthy volunteers received 6 g eicosapentaenoic acid ethyl ester daily for 6 weeks, followed by a 4 week wash‐out and then 18 g daily for 6 weeks. 2. There was inhibition of neutrophil leukotriene B4 and 5‐ hydroxyeicosatetraenoic acid synthesis, with no significant differences between low and high dose. 3. There was a dose dependent increase in leukotriene B5 and 5‐hydroxyeicosatetraenoic acid acid synthesis. 4. Plasma triglycerides were reduced maximally on 6 g daily, with no greater suppression at 18 g daily. 5. Plasma cholesterol was only suppressed significantly at 18 g daily. 6. The 6 g daily dose was well tolerated but the 18 g daily dose produced diarrhoea and steatorrhoea.