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The effect of age on the pharmacokinetics of ifosfamide.
Author(s) -
Lind MJ,
Margison JM,
Cerny T,
Thatcher N,
Wilkinson PM
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03754.x
Subject(s) - ifosfamide , pharmacokinetics , volume of distribution , medicine , pharmacology , metabolic clearance rate , distribution (mathematics) , clearance , lung cancer , oncology , urology , chemotherapy , cisplatin , mathematical analysis , mathematics
The effect of age on the pharmacokinetics of ifosfamide was studied in 20 patients with advanced non small cell lung cancer. A positive correlation was found between the elimination half‐life of ifosfamide and age (r = 0.48, 0.05 less than P less than 0.01). This was due to an increase in volume of distribution with age (r = 0.66, 0.001 less than P less than 0.01). Total plasma clearance, renal clearance and non renal clearance did not change with age. Age did not affect the autoinduction of ifosfamide metabolism. Further studies are needed to demonstrate any adverse effects of ifosfamide in the elderly.