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Comparative effects of ciprofloxacin and lomefloxacin on the oxidative metabolism of theophylline.
Author(s) -
Robson RA,
Begg EJ,
Atkinson HC,
Saunders DA,
Frampton CM
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03669.x
Subject(s) - theophylline , lomefloxacin , ciprofloxacin , pharmacology , medicine , drug interaction , crossover study , bronchodilator , pharmacokinetics , chemistry , antibiotics , norfloxacin , biochemistry , alternative medicine , pathology , placebo , asthma
Nine healthy male volunteers were studied to assess the interaction between theophylline and ciprofloxacin and to assess whether a similar interaction occurred with lomefloxacin, using a randomised, crossover design. Subjects received theophylline 125 mg 8 hourly with and without lomefloxacin 400 mg 12 hourly or ciprofloxacin 500 mg 12 hourly for 7 days. Ciprofloxacin treatment lowered total theophylline clearance by 27%, owing to a decreased clearance via 1‐, 3‐demethylation and 8‐ hydroxylation. Lomefloxacin treatment did not alter theophylline clearance. Ciprofloxacin, at usual clinical doses, could cause a clinically significant interaction when co‐administered with theophylline.