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Lack of effect of spiramycin on cyclosporin pharmacokinetics [letter; comment]
Author(s) -
Kessler M,
Netter P,
Renoul HE,
Trechot P,
Dousset B,
Bannwarth B
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03652.x
Subject(s) - library science , humanities , philosophy , computer science
This study confirms our previously published data showing that spiramycin does not increase plasma cyclosporin concentrations in renal transplant patients. Our study included seven cadaveric renal transplant patients (three men and four women), aged 24 to 59 years. The mean duration of graft was 8 months. All patients were treated with cyclosporin in association with prednisone. Plasma cyclosporin concentrations were measured using the polyclonal Sandoz RIA kit