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The effect of age on serum concentrations of albumin and alpha 1‐acid glycoprotein.
Author(s) -
Veering BT,
Burm AG,
Souverijn JH,
Serree JM,
Spierdijk J
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03620.x
Subject(s) - orosomucoid , albumin , medicine , nephelometry , endocrinology , serum albumin , glycoprotein , alpha (finance) , human serum albumin , blood proteins , serum concentration , chemistry , immunology , biochemistry , antibody , surgery , construct validity , patient satisfaction
1. Human serum albumin (HSA) concentrations and alpha 1‐acid glycoprotein (AAG) concentrations were measured in 68 subjects, 35 males and 33 females, aged 20‐90 years without evidence of acute or chronic inflammatory disease or malignancy. Subjects were drug free for at least 1 month. HSA and AAG concentrations were measured using rate nephelometry. 2. Age had no effect on alpha 1‐acid glycoprotein concentration, whereas plasma albumin levels decreased as a function of age in both sexes. We observed no differences between males and females in the plasma concentrations of HSA and AAG. 3. These data show that in healthy subjects the HSA concentration decreases with increasing age, whereas age, uncomplicated by disease does not influence AAG concentration.