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Effects of aspirin upon the flushing reaction induced by niceritrol.
Author(s) -
Jay RH,
Dickson AC,
Betteridge DJ
Publication year - 1990
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1990.tb03611.x
Subject(s) - aspirin , flushing , premedication , medicine , placebo , dosing , anesthesia , prostaglandin , pharmacology , endocrinology , alternative medicine , pathology
The usefulness of niceritrol as a lipid‐lowering agent is limited by a prostaglandin‐mediated flushing reaction after each dose occurring in the early stages of treatment. We have tested the effect of premedication with aspirin on the reaction to 250 mg niceritrol in 30 healthy male volunteers using both subjective and observed assessments of severity. Both 300 mg and 600 mg of aspirin significantly reduced the severity of flushing when compared with placebo. No significant difference was seen between the two dose levels. Prior dosing with aspirin may increase acceptability of niceritrol and hence improve compliance.