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Co‐administration of ciprofloxacin and cyclosporin: lack of evidence for a pharmacokinetic interaction.
Author(s) -
Tan KK,
Trull AK,
Shawket S.
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05414.x
Subject(s) - pharmacokinetics , pharmacology , ciprofloxacin , medicine , administration (probate law) , pharmacokinetic interaction , drug interaction , antibiotics , chemistry , political science , biochemistry , law
Ciprofloxacin is widely reported to lower theophylline clearance in patients. Since cyclosporin and theophylline are metabolized by cytochrome P‐450 enzymes in the human liver, we investigated whether ciprofloxacin could alter the pharmacokinetics of cyclosporin in healthy volunteers. There was no significant difference (P greater than 0.05) in the pharmacokinetic parameters estimated for cyclosporin without and during ciprofloxacin administration. The results of the present study suggest that ciprofloxacin is unlikely to affect the pharmacokinetics of cyclosporin to a clinically important extent at a dosage of 500 mg twice a day.