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Neuromuscular blockade with vecuronium in paediatric patients with burn injury.
Author(s) -
Mills AK,
Martyn JA
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05408.x
Subject(s) - neuromuscular blockade , medicine , burn injury , pharmacodynamics , anesthesia , ed50 , total body surface area , neuromuscular transmission , body surface area , pharmacokinetics , pharmacology , surgery , receptor
1. The effect of body surface area (BSA) burn injury on neuromuscular pharmacodynamics of vecuronium was evaluated. 2. The neuromuscular responses of 15 burned children were compared with those in five controls. 3. The effective dose for 50% suppression of twitch tension (ED50) was 34 micrograms kg‐1 for patients with less than 40% BSA burn, 55 micrograms kg‐1 for 40‐60% BSA burn, and 65 micrograms kg‐1 for patients with greater than 60% BSA burn. These values were significantly higher than the value for control patients, which was 18 micrograms kg‐1. 4. Burn injury induces a resistance to the neuromuscular effects of vecuronium, the magnitude of which is related to burn size.