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Cyclosporin‐erythromycin interaction in renal transplant patients.
Author(s) -
Gupta SK,
Bakran A.,
Johnson RW,
Rowland M.
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05396.x
Subject(s) - erythromycin , bioavailability , metabolite , pharmacokinetics , pharmacology , oral administration , drug interaction , renal transplant , medicine , absorption (acoustics) , kidney , antibiotics , chemistry , biochemistry , physics , acoustics
1. The interaction between cyclosporin (CyA) and erythromycin was studied in renal transplant patients following oral and intravenous administration of CyA. 2. Blood and plasma CyA concentrations and blood concentrations of metabolite 17 were measured by h.p.l.c. 3. Erythromycin produced almost a two‐fold increase in bioavailability, from 36% to 60%; with a small (13%) decrease in clearance of CyA. 4. The metabolite 17 data further support the postulate that erythromycin increases the absorption of CyA rather than inhibits its metabolism, as generally believed.