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Lack of effect of terfenadine on theophylline pharmacokinetics and metabolism in normal subjects.
Author(s) -
Brion N.,
Naline E.,
Beaumont D.,
Pays M.,
Advenier C.
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05383.x
Subject(s) - theophylline , terfenadine , pharmacokinetics , oral administration , pharmacology , bronchodilator , chemistry , distribution (mathematics) , medicine , asthma , mathematical analysis , mathematics
The pharmacokinetics of oral theophylline (250 mg) and the production of its metabolites (3‐methylxanthine, 1‐methyluric acid, 1,3‐ dimethyluric acid) were studied before and after the administration of oral terfenadine (120 mg twice daily for 16 days) in 10 healthy volunteers. Comparison of volumes of distribution, elimination half‐ lives, areas under the plasma concentration‐time curves, plasma clearance of theophylline and elimination of theophylline metabolites indicated that terfenadine had no significant effect on theophylline pharmacokinetics and metabolism.