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Lack of effect of paracetamol on the pharmacokinetics of chloramphenicol.
Author(s) -
Stein CM,
Thornhill DP,
Neill P.,
Nyazema NZ
Publication year - 1989
Publication title -
british journal of clinical pharmacology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.216
H-Index - 146
eISSN - 1365-2125
pISSN - 0306-5251
DOI - 10.1111/j.1365-2125.1989.tb05359.x
Subject(s) - chloramphenicol , pharmacokinetics , pharmacology , medicine , oral administration , half life , antibiotics , chemistry , biochemistry
The effect of oral paracetamol (1 g) on the pharmacokinetics of oral chloramphenicol (500 mg) was examined in five adult male Zimbabwean patients with normal hepatic and renal function. No significant alteration of half‐life, area under the concentration‐time curve or peak concentration of chloramphenicol was observed. The previously reported, potentially serious interaction between chloramphenicol and paracetamol administered intravenously was not observed with the more commonly used oral preparations.